Scientific Areas of Integrated Review Groups (IRGs)


For a listing of the Scientific Review Officer and membership roster for each study section, click on the study section roster under the study section name within an IRG listed below or go to the study section index (study sections listed alphabetically) and click on the specified roster next to the name of the study section.

Cell Biology IRG [CB]

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[CSRS Roster]


The Cellular Signaling and Dynamics (CSD) study section will be restructured and renamed the Cellular Signaling and Regulatory Systems (CSRS) study section and will review applications that focus on the initiation and execution of programs that control cellular homeostasis and physiology. A distinguishing characteristic of these applications is an emphasis on signaling networks and the coordination of processes related to cell proliferation, survival, and growth.

 

Specific areas include:

  • Integrative cell physiology, e.g., stress, clocks, cellular modeling
  • Mitosis and meiosis as related to cell cycle regulation
  • Cell differentiation and transformation
  • Cell size and mass, asymmetry and polarity
  • Molecular control of proliferation and senescence
  • Programmed cell death and apoptosis particularly in the context of stress, growth, and transformation
  • Proteolytic mechanisms associated with cell cycle, senescence, and death
  • Application of state-of-the-art technologies such as imaging and computational modeling of cellular signaling networks

The CSRS Study Section has the following shared interests within the CB IRG: 

With the ICI Study Section:  Cell differentiation, transformation and polarity are shared areas of interest. Applications focused on regulation of these processes by the extracellular matrix or cell-cell signaling or those related to morphogenesis could be reviewed by ICI. Those focused on intracellular signaling networks and pathways related to these processes could be reviewed by CSRS.

 

With the MBPP Study Section: Post-translational modifications such as  ubiquitin/proteasome, sumolation, etc. are areas of shared interest. Applications related to trafficking of modified proteins and modifying enzymes and proteasomal proteolysis could be reviewed by MBPP. Those focused on to the signaling networks regulating these mechanisms in the context of the cell cycle or cell senescence could be reviewed by CSRS.

 

With the CSF Study Section: Cell signaling is an area of shared interest. Applications focused on the translocation or recycling of signaling receptors and molecules could be reviewed in CSF. Those focused on signaling networks and cascades could be reviewed in CSRS.

 

With the MIST Study Section: Cell signaling is an area of shared interest. Applications focused on biochemical and molecular mechanisms of G-protein and 7TM receptors could be reviewed by MIST. Those with an emphasis on signaling networks and the coordination of processes related to the cell cycle, proliferation, survival and growth could be reviewed by CSRS.

The CSRS study sections have the following shared interests outside the IRG:

With the Bioengineering Sciences and Technologies [BST] IRG: Shared areas of interest are computational biology and cell imaging. If the focus is on the development of new imaging technologies or computational methods, the assignment could be to BST. If the focus is the use of imaging technologies or computational methods to answer questions related to cellular signaling pathways or networks, assignment could be to CSRS. An application that combines bioengineering and cell biology could be assigned according to the focus of the research.

With the Biology of Development and Aging [BDA] IRG: Shared areas of interest are intracellular signaling. If the emphasis is specifically on a developmental or aging question, assignment could be to BDA. If the focus is on the fundamental study of cellular signaling processes, assignment to could be to CSRS.

With the Genes, Genomes and Genetics IRG (GGG):  Shared interests include signal transduction pathways, cell cycle control and regulation. If the focus is on molecular genetic mechanisms or regulation of DNA metabolism or gene expression, assignment could be to GGG. If the focus is on the elucidation of signaling pathways and networks that regulate cell cycle control and apoptosis, assignment could be to CSRS.

With the Organ-system/Disease IRGs - Hematology [HEME]; Cardiovascular Sciences [CVS]; Endocrinology, Metabolism, Nutrition, & Reproductive Sciences [EMNR]; Musculoskeletal, Oral, & Skin Sciences [MOSS]; Digestive Sciences [DIG]; Respiratory Sciences [RES]; Oncological Sciences [ONC]; and Renal & Urological Sciences [RUS]:  Shared areas of interest are cellular signaling processes in the context of a specific organ or disease. If the focus is physiological, i.e., the scientific question relates to a specific organ system or disease, assignment could be to the appropriate IRG. If the main focus is basic, i.e., the scientific question is focused on fundamental cellular signaling processes which may be applicable to multiple diseases or organ systems, or where a particular cell or tissue type is chosen only as a model system, assignment could be to CSRS.

With the Neuroscience IRGs - Molecular, Cellular & Developmental Neuroscience [MDCN]; Integrative, Functional, & Cognitive Neuroscience [IFCN]; and Brain Disorders & Clinical Neuroscience [BDCN]: Shared areas of interest are cellular signaling processes in neuronal systems. If the focus is on processes specific to the nervous system or on a physiological or clinical problem, assignment could be to the appropriate neuroscience IRG. If the primary focus is on the fundamental study of cellular signaling processes and the nervous system is used as a convenient model, assignment could be to CSRS.


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[MIST Roster]

 

The Molecular and Integrative Signal Transduction (MIST) study section will review applications that focus broadly on basic molecular mechanisms of signaling among cells. These applications will focus on the biochemical and structural mechanisms of signal transduction, including G-proteins, seven-transmembrane protein (7TM) coupled receptors, and their regulation. Further, the associated kinases, phosphatases and lipid signaling mechanisms and cross-talk with other pathways are of interest. Integrative studies may involve a variety of organisms that advance the field whether uni- or multi-cellular, bacterial or mammalian.

 

Specific areas include:

 

  • Biochemical and structural mechanisms of receptor signal
    transduction, including G-proteins and 7TM receptors
  • Molecular mechanisms of protein-protein interactions among signaling molecules
  • Serine and tyrosine protein kinases associated with signal transduction mechanisms
  • Protein phosphatases associated with signal transduction mechanisms
  • Second messenger mechanisms including lipid signaling molecules
  • Related metabolic studies including drugs and inhibitors
  • Regulatory mechanisms controlling signaling including regulator of G-protein signaling (RGS) proteins
  • Computer simulations and modeling of signaling complexes and pathway components

The MIST Study Section has the following shared interests within the CB IRG:

 

With the CSRS Study Section:  Cell signaling is an area of shared interest. Applications focused on biochemical and molecular mechanisms of G-protein and 7TM receptors could be reviewed by MIST. Those with an emphasis on signaling networks and the coordination of processes related to the cell cycle, proliferation, survival and growth could be reviewed by CSRS.

 

With the CSF Study Section: Cell signaling mechanisms are an area of shared interest. Applications focused on the translocation or recycling of signaling receptors and molecules could be reviewed in CSF. Those focused on molecular and biochemical aspects of signal transduction could be reviewed in MIST.

 

With the ICI Study Section: Receptor signal transduction mechanisms are an area of shared interest. Applications focused on crosstalk by adhesion receptors and other signaling pathways could be reviewed in ICI. Those focused on general molecular and biochemical aspects of signal transduction pathways could be reviewed in MIST.

 

With the MBPP Study Section: Cell signaling mechanisms including lipid signaling are an area of shared interest. Applications focused on the translocation or recycling of signaling molecules or complexes could be reviewed in MBPP. Those focused on general molecular and biochemical aspects of signal transduction pathways could be reviewed in MIST.

 

With the NDT Study Section: Cell signaling mechanisms are an area of shared interest. Applications focused on signaling mechanisms and networks that target the nucleus could be reviewed by NDT. Those focused on molecular and biochemical aspects of cytoplasmic signal transduction could be reviewed in MIST.

 

 

The MIST Study Section has the following shared interests outside the CB IRG:


With the Bioengineering Sciences and Technologies [BST] IRG: Shared areas of interest are computational biology and cell imaging.  If the focus is on the development of new imaging technologies or computational methods, the assignment could be to BST. If the focus is the use of imaging technologies or computational methods to answer questions related to signaling complexes and pathway components, assignment could be to MIST. An application that combines bioengineering and cell biology could be assigned according to the focus of the research.

With the Biological Chemistry and Macromolecular Biophysics [BCMB] IRG: Shared areas of interest are protein-ligand interactions, drug discovery and macromolecular studies of metabolic pathways and networks. If the focus is on high resolution structural, synthetic or biophysical studies of these systems, assignment could be to BCMB. If the focus is on the functional and mechanistic or biochemical studies of these systems, or on G-protein receptors, assignment could be to MIST.

With the Cardiovascular Sciences [CVS] IRG: Shared areas of interest are the regulation and signaling of adrenergic and other G-protein coupled receptors. If the focus is on the physiological question related to hypertension, regional and microcirculation, or lymphatic flow, assignment could be to CVS. If the focus is on a fundamental cellular and molecular understanding of the regulation and signaling of adrenergic receptors and other G-protein coupled receptors, including the activation and regulation of the relevant phospholipases, kinases, phosphatases and cyclases, assignment could be to MIST. 

With the Oncological Sciences [ONC] IRG – Shared areas of interest are signal transduction pathways mediated by phosphatases and other proteins. If the main focus is on cancer biology or oncogenic transformation, assignment could be to ONC. If the scientific question is focused on basic mechanistic studies or elucidation of fundamental signal transduction complexes, using cancer as a model system, assignment could be to MIST.

With the Immunological Sciences [IMM] IRG: Shared areas of interest are intracellular signaling and the biochemistry of second messengers including lipid mediators and reactive nitrogen and oxygen species. If the scientific focus is on an immunological question, assignment could be to IMM. If cells of the immune system are used as a model system to elucidate fundamental signal transduction mechanisms, assignment could be to MIST.


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[NDT Roster]

The Nuclear Dynamics and Transport Study Section will consider research applications concerning nuclear aspects of growth, cell cycle control, and regulation of programmed cell death and apoptosis. Nuclear architecture, as related to the assembly of the molecular machinery responsible for RNA synthesis and processing, DNA replication, as well as trafficking into and out of the nucleus will be considered. In addition, many signaling pathways ultimately converge on the nucleus. Cytoskeletal structure and dynamics, the movement of protein and RNA cargoes utilizing molecular motors, and organelle biogenesis will also be covered. Nuclear function, structure, and motor driven movement are also integral to mitosis and meiosis, as well as programmed cell death and apoptosis.

Specific areas include, but are not limited to NDT:

  • Proliferation and growth control
  • Cell cycle regulation, mitosis and checkpoints
  • Meiosis
  • Programmed cell death and apoptosis
  • Filaments, motors and cargoes
  • Nuclear architecture, nuclear envelope structure and transport
  • Signaling mechanisms and networks that target the nucleus
  • Telomeres

The NDT Study Section has the following shared interests within the CB IRG:


With the CSRS Study Section:  Cell cycle control and mitosis is an area of shared interest. Applications focused on cell cycle regulation related to nuclear architecture, chromosome function and checkpoints could be reviewed by NDT.  Those focused on signaling pathways involved in cell cycle regulation could be reviewed in CSRS.

 

With the CSF Study Section: Motors, filaments and cargo are areas of shared interest. Applications focused on the role of motors in control of cell division and chromosome dynamics in mitosis and meiosis could be reviewed in NDT. Those focused on motor-based transport of vesicle cargoes or on the role of motors and filaments in cell motility could be reviewed in CSF.

 

With the MBPP Study Section: Intracellular trafficking is an area of shared interest. Applications focused on trafficking into and out of the nucleus could be reviewed by NDT. Those focused on general cytoplasmic trafficking processes could be reviewed by MBPP.

With the MIST Study Section: Cell signaling mechanisms are an area of shared interest. Applications focused on signaling mechanisms and networks that target the nucleus could be reviewed by NDT. Those focused on molecular and biochemical aspects of cytoplasmic signal transduction could be reviewed in MIST.

 

The NDT Study Section has the following shared interests outside the CB IRG:


With the Bioengineering Sciences and Technologies [BST] IRG: Shared areas of interest are computational biology and cell imaging.  If the focus is on the development of new imaging technologies or computational methods, the assignment could be to BST. If the focus is the use of imaging technologies or computational methods to answer questions related to nuclear architecture or nucleocytoplasmic transport, assignment could be to NDT. An application that combines bioengineering and cell biology could be assigned according to the focus of the research.

 

With the Genes, Genomes and Genetics [GGG] IRG: Shared areas of interest are chromosome structure and dynamics, nucleocytoplasmic transport, cell cycle control, meiosis, RNA processing and nuclear protein turnover. If the focus is on nuclear envelope and nuclear pore structure and assembly, including the role of lamins, nucleoporins and cytoskeletal proteins; chromatin packaging and remodeling; and ribonucleoprotein assembly and transport through nuclear pore complexes, assignment could be to NDT. Applications focused on the molecular machinery controlling mitotic and meiotic cell divisions, including, but not limited to, the actin- and microtubule-based cytoskeleton as well as synaptonemal and kinetochore proteins could be assigned to NDT. Applications focused on signaling mechanisms targeting the nucleus, nuclear protein turnover, cell cycle regulation and programmed cell death could be assigned to NDT if the emphasis is on protein function and regulation. Applications focused primarily on nucleic acids and/or the fundamental molecular mechanisms regulating DNA replication and repair, transcription and translation could be assigned to the GGG IRG.

 

With the Endocrinology, Metabolism, Nutrition, & Reproductive Sciences [EMNR] IRG: Cell biology studies of gametogenesis and reproductive tract remodeling are shared interests between EMNR and NDT. If the focus is reproduction, assignment could be to the EMNR IRG. If the focus is cell biology, assignment could be to NDT.

 

With the Oncological Sciences [ONC] IRG: Cell growth and cycle control are areas of shared interest. If an application is focused on normal cell biological processes, assignment could be to NDT. If an application is focused on tumor cell biological processes, assignment could be to the ONC IRG. An application that combines normal and tumor cell biological processes could be assigned according to the focus of the research.


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[ICI Roster]

The Intercellular Interactions Study Section has an emphasis on how cells interact with both their environment and with neighboring cells, and how this regulates processes associated with cell growth, proliferation, differentiation and higher order complexity in tissues and development, including the synthesis of glycoproteins. ICI is also focused on how extracellular signals regulate the cytoskeleton and impact cell behavior.

Specific areas include, but are not limited to:

  • Synthesis, assembly, remodeling and glycosylation of extracellular matrix, and the role of carbohydrates in cell-cell adhesive structures

  • Cell surface adhesive structures in relation to the cytoskeleton, cell polarity and cell proliferation, differentiation and survival

  • Regulation of assembly and function of channels, transporters and gap junctions

  • The flow of extracellular signals between distinct cells types, cell populations and ECM

  • Cell migration, cell-cell fusion, cell organization and morphogenesis as related to tissue organization and development

  • Crosstalk between adhesion receptors and other signaling pathways and regulated proteolysis at the cell surface

The ICI Study Section has the following shared interests within the CB IRG: 

With the CSRS Study Section:  Cell differentiation, transformation and polarity are shared areas of interest. Applications focused on regulation of these processes by the extracellular matrix or cell-cell signaling or those related to morphogenesis could be reviewed by ICI. Those focused on intracellular signaling networks and pathways related to these processes could be reviewed by CSRS.

 

With the MBPP Study Section: Glycobiology is an area of shared interest. ICI is a primary home for glycobiology applications, with MBPP providing a secondary home. Applications focused on intracellular glycosylation processes involving trafficking along the secretory pathway could be reviewed by MBPP. Those focused on cell surface and cell adhesion related glycosylation processes could be reviewed by ICI.

 

With the CSF Study Section: The extracellular matrix interactions, cell motility, and cell adhesion are shared areas of interest. Applications with a focus on cell migration, fusion or morphogenesis as related to tissue organization and development could be reviewed by ICI. Those with a focus on the role of cytoskeletal components on these processes could be reviewed in CSF.

 

With the MIST Study Section: Receptor signal transduction mechanisms are an area of shared interest. Applications focused on crosstalk by adhesion receptors and other signaling pathways could be reviewed in ICI. Those focused on general molecular and biochemical aspects of signal transduction pathways could be reviewed in MIST


The ICI study section has the following shared interests outside the CB IRG:

With the Bioengineering Sciences and Technologies [BST] IRG: Shared areas of interest are cell adhesion, differentiation, growth and migration. If the focus is on the development of new technologies, matrices or scaffolds to model these processes, the assignment could be to BST. If the focus is the use of new technologies, matrices or scaffolds to provide insights into these cellular processes, the assignment could be to ICI. An additional shared area of interest is microscopic imaging. The development of new imaging technologies could be assigned to BST. The use of new imaging technologies to answer questions related to intercellular processes could be assigned to ICI. An application that combines bioengineering and cell biology could be assigned according to the focus of the research.

With the Biological Chemistry and Macromolecular Biophysics [BCMB] IRG: Shared areas of interest include glycobiology. High-resolution structural, biophysical or synthetic studies could be assigned to BCMB. Functional studies of glycosylation in cell adhesion, cell surface receptors and the extracellular matrix could be assigned to ICI.

With the Biology of Development and Aging [BDA] IRG: Shared areas of interest are cell differentiation, proliferation and morphogenesis as related to tissue organization and development are shared interests. If the focus is the morphogenetic pathways associated with organogenesis or gamete development, assignment could be to BDA. If the focus is the study of fundamental cellular processes associated with organization, proliferation, morphogenesis or differentiation, assignment could be to ICI.

With the Cardiovascular Sciences [CVS] IRG: Shared areas of interest include the extracellular matrix, intercellular communication, receptor biology and cell differentiation. If the focus is on the physiology of the cardiovascular system, the assignment could be to CVS. If the focus is on its use as a model system to understand basic cell biological processes, assignment could be to ICI.

With the Digestive Sciences [DIG] and Respiratory Sciences [RES] IRGs: Shared areas of interest are cell adhesion, cell-cell interactions, cell differentiation and cell migration. If the focus is on the physiology of the digestive system, assignment could be to DIG. If the focus is its use as model system to understand basic cell biological processes, the assignment could be to ICI.

With the Molecular, Cellular and Developmental Neurosciences [MDCN] IRG: Shared areas of interest are cell surface and extracellular matrix molecules in cell recognition and function. If the focus is on the physiology of the nervous system, the assignment could be to MDCN. If the focus its use as a model system to elucidate basic intercellular processes and mechanisms, assignment could be to ICI.

With the Musculoskeletal, Oral and Skin Sciences [MOSS]: Shared areas of interest are the extracellular matrix, cell matrix interactions, extracellular matrix: cell matrix interaction and signaling. If the focus is on the physiology of the musculoskeletal, oral or skin, assignment could be to MOSS. If the focus is its use as model system to understand basic cell biological processes, the assignment could be to ICI.

With the Oncological Sciences [ONC] IRG: Shared areas of interest are cell adhesion, cell-cell interactions, extracellular matrix, gap junctions, adherens, and tight junctions. If the focus is on cancer biology, the assignment could be to ONC. If the focus is the elucidation of basic intercellular processes and mechanisms, assignment could be to ICI.

 


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[CSF Roster]

The Cell Structure and Function Study Section will focus on the molecular structure and function of cells, with emphasis on applications concerned with membrane structure and function, membrane traffic, organelle biogenesis, extracellular matrix (ECM), cell motility and the cytoskeleton, and their related signaling pathways.

Specific areas include, but not limited to CSF:

  • Organelle biogenesis (For example mitochondria, chloroplasts, peroxisomes and lysosomes/vacuoles), including organelle proliferation, segregation, and dynamics

  • Targeting, translocation, and processing of newly synthesized proteins at membrane compartments

  • Cell motility, cytoskeletal dynamics, including their role in morphogenesis

  • ECM interactions with the cytoskeleton, and assembly of receptors into junctions and adhesions

  • Mechanical properties of cells and the ECM

  • Signaling mechanisms related to membrane traffic, cell motility, and cell adhesion.

The CSF Study Section has the following shared interests within the CB IRG: 

With the CSRS Study Section:  Cell signaling is an area of shared interest. Applications focused on the translocation or recycling of signaling receptors and molecules could be reviewed in CSF. Those focused on signaling networks and cascades could be reviewed in CSRS.

 

With the ICI Study Section: Cell adhesion, cell motility and extracellular matrix (ECM) and ECM receptor interaction are areas of shared interest.  Applications focused on the involvement of the cytoskeleton in these processes or interactions could be reviewed in CSF. Those focused on regulation of these processes or interactions by stimuli in the extracellular environment could be reviewed in ICI.

 

With the MBPP Study Section: Intracellular trafficking and membrane structure are an area of shared interest. Applications focused on trafficking processes that emphasize the association with the cytoskeleton could be reviewed in CSF. Applications focused on general trafficking processes could be reviewed in MBPP.

 

With the NDT Study Section: Motors, filaments and cargo are areas of shared interest. Applications focused on motor-based transport of vesicle cargoes or on the role of motors and filaments in cell motility could be reviewed in CSF. Those focused on the role of motors in control of cell division and chromosome dynamics in mitosis and meiosis could be reviewed in NDT.

 

With the MIST Study Section: Cell signaling mechanisms are an area of shared interest. Applications focused on the translocation or recycling of signaling receptors and molecules could be reviewed in CSF. Those focused on molecular and biochemical aspects of signal transduction could be reviewed in MIST.


The CSF study section has the following shared interests outside the CB IRG:

With the Bioengineering Sciences and Technologies [BST] IRG: Shared areas of interest are computational biology and cell imaging.  If the focus is on the development of new imaging technologies or computational methods, the assignment could be to BST. If the focus is the use of imaging technologies or computational methods to answer questions related to cellular structure and function, assignment could be to CSF. An application that combines bioengineering and cell biology could be assigned according to the focus of the research.

With the Biological Chemistry and Macromolecular Biophysics [BMCB] IRG:  Shared areas of interest are cell mechanics, the cytoskeleton, and molecular motors. If the focus is on high-resolution structural or biophysical studies of these systems, assignment could be to BCMB. If the focus is on the biological functions and mechanisms of these systems, assignment could be to CSF.

 

With the Cardiovascular Sciences [CVS] IRG:  Shared areas of interest are cellular and molecular studies of vascular structure and function of smooth muscle. When the focus is an understanding of the biology and physiology of the cardiovascular system, assignment could be to the CVS IRG. If the focus is on a general cellular or molecular understanding of the cytoskeleton, assignment could be to CSF.

 

With the Digestive Sciences [DIG] and Respiratory Sciences [RES] IRGs: Shared areas of interest are intracellular trafficking, cytoskeleton function, and molecular motors. If the focus is on the physiology of the digestive system, assignment could be to DIG. If the focus is its use as model system to understand basic cell biological processes, the assignment could be to CSF.

 

With the Hematology [HEME] IRG:  Shared interests are in the structure and function of filamentous organelles and membranes. If the focus is on the physiology of the vascular system, assignment could be to HEME. If the focus is on its use as a model system to elucidate basic processes and mechanisms related to cell structure and function, assignment could be to CSF.

 

With the Molecular, Cellular and Developmental Neurosciences [MDCN] IRG: Shared areas of interest are the cytoskeleton and intracellular trafficking. If the focus is on the physiology of the nervous system, assignment could be to MDCN. If the focus is on its use as a model system to elucidate basic cell processes, structure and mechanisms, assignment could be to CSF.

 

With the Musculoskeletal, Oral and Skin Sciences [MOSS] IRG:  Shared areas of interest are muscle structure and the extracellular matrix. If the focus is on the physiology of the musculoskeletal, oral or skin, assignment could be to MOSS. If the focus is its use as model system to understand basic cell structural and functional processes, the assignment could be to CSF.

With the Oncological Sciences [ONC] IRG:  Shared areas of interest are cell adhesion, motility, and junctions and extracellular matrix interaction with the cytoskeleton. If the focus is oncological processes, assignment could be to ONC. If the focus is cell biological processes, assignment could be to CSF. An application that combines normal and tumor cell biological processes could be assigned according to the focus of the research.


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[MBPP Roster]

The Membrane Biology and Protein Processing Study Section will focus on cellular membranes and protein maturation and degradation. Specific topics include membrane biogenesis; post-translational modification and protein folding; membrane biology including membrane structure and function; vesicular membrane traffic; transport of small molecules across membranes; cell stress response; metabolic pathways including lipid metabolism; degradative processes and proteolytic mechanisms of programmed cell death and apoptosis. Signaling mechanisms regulating these processes would also be appropriate.

Specific areas include, but not limited to MBPP:

  • Regulation, functions and mechanisms of protein maturation, including folding, chaperone action, post-translational modification, and proteolytic processing
  • Membrane traffic in the endocytic and exocytic pathways; mechanisms of protein quality control and sorting; and mechanisms of vesicle formation, targeting and fusion 

  • Organization of proteins, carbohydrates, and lipids in cell membranes; metabolism and trafficking of lipids; interactions between proteins, glycoproteins, glycolipids, and lipids; regulation of signaling by lipid domains
  • Cellular physiology and molecular mechanisms of regulation of ion and small molecule transport across membranes via channels, transporters or gap junctions
  • Integrative cell physiology (e.g., stress, metabolism, clocks, cellular modeling)
  • Degradation of proteins by the ubiquitin/proteasome and lysosomes; limited proteolysis by caspases and calpains; and degradation of extracellular matrix and other macromolecules
  • Mechanisms of necrosis and apoptosis, with an emphasis on regulation of caspases, proteolytic pathways responsible for elimination of dead cells, and mitochondrial proteolytic pathways

The MBPP Study Section has the following shared interests within the CB IRG: 

With the CSRS Study Section:  Post-translational modifications such as  ubiquitin/proteasome, sumolation, etc. are areas of shared interest. Applications related to trafficking of modified proteins and modifying enzymes and proteasomal proteolysis could be reviewed by MBPP. Those focused on to the signaling networks regulating these mechanisms in the context of the cell cycle or cell senescence could be reviewed by CSRS.

 

With the ICI Study Section: Glycobiology is an area of shared interest. ICI is a primary home for glycobiology applications, with MBPP providing a secondary home. Applications focused on intracellular glycosylation processes involving trafficking along the secretory pathway could be reviewed by MBPP. Those focused on cell surface and cell adhesion related glycosylation processes could be reviewed by ICI.

 

With the CSF Study Section: Intracellular trafficking and membrane structure are an area of shared interest. Applications focused on general trafficking processes could be reviewed in MBPP. Those focused on trafficking processes that emphasize the association with the cytoskeleton could be reviewed in CSF.

 

With the MIST Study Section: Cell signaling mechanisms including lipid signaling are an area of shared interest. Applications focused on the translocation or recycling of signaling molecules or complexes could be reviewed in MBPP. Those focused on general molecular and biochemical aspects of signal transduction pathways could be reviewed in MIST.

 

With the NDT Study Section: Intracellular trafficking is an area of shared interest. Applications focused on general cytoplasmic trafficking processes could be reviewed by MBPP. Those focused on trafficking into and out of the nucleus could be reviewed by NDT.

The MBPP study section has the following shared interests outside the IRG:

With the Biological Chemistry and Macromolecular Biophysics IRG [BCMB] IRG:  Shared areas of interest are membrane architecture; membrane protein structure; function of membrane proteins including channels, receptors and membrane-associated enzymes; and protein folding, assembly into macromolecular complexes and their function.  If the focus is a high-resolution structural or biophysical understanding, assignment could be to BCMB. If the focus is a biological understanding, assignment could be to MBPP.

 

With the Digestive Diseases [DIG] IRG: Shared areas of interest include mechanisms of signal transduction, polarized vesicle-mediated membrane trafficking, secretion and absorption, intercellular junctions, apoptosis, epithelial barrier function and the physiology of ion channels and transporters.  If the focus is on the physiology of the digestive system, assignment could be to DIG. If the focus is its use as model system to understand basic cellular processes or function, assignment could be to MBPP.

 

With the Bioengineering Sciences and Technologies IRG [BST IRG]: Shared areas of interest include microscopic imaging of fixed and live cells, and computational modeling.  If the focus is on the development of new imaging technologies or computational methods, the assignment could be to BST. If the focus is the use of imaging technologies or computational methods to answer questions related to cell biological processes, assignment could be to MBPP. An application that combines bioengineering and cell biology could be assigned according to the focus of the research.

With the Genes, Genomes and Genetics IRG (GGG):  Shared areas of interest are protein synthesis and post-translational modifications, encompassing ubiquitination leading to protein degradation; and signal transduction pathways.  If the focus is on the fundamental mechanisms regulating gene expression at transcriptional and translational levels, assignment could be to the GGG IRG. If the focus is on protein function and folding and protein-protein interactions, assignment could be to the MBPP study section.

With the Immunology [IMM] IRG:  Shared areas of interest are signal transduction as it relates to ion fluxes at the cell surface and intracellular stores; intracellular sorting and vesicle-mediated trafficking of membrane proteins and lipids and the post-translational modifications that regulate these processes. If the focus is on cellular processes restricted to lymphocytes and other cells of the immune system, or on answering an immunological question, assignment could be to the IMM IRG. If the focus is on conserved cellular processes common to various cell types, including cells of the immune system, or on answering a general cell biological question, assignment could be to MBPP.

 

With the Infectious Diseases and Microbiology IRG (IDM):  Shared areas of interest are protein synthesis and post-translational modifications; protein secretion, localization and assembly into macromolecular complexes; and intercellular signaling and communication.  If the focus is on those prokaryotes that emphasize the pathogenicity of eukaryotic microorganisms, assignment could be to the IDM IRG. If the focus is on using eukaryotic model systems to examine conserved cellular processes, assignment could be to MBPP.

 

With the Molecular, Cellular and Developmental Neuroscience IRG (MDCN):  Shared areas of interest include general aspects of cell biology; membrane structure; the molecular regulation of membrane (protein and lipid) trafficking along the exocytotic, endocytic and recycling pathways; localization and function of transporters, receptors and ion channels; apoptosis; and intracellular signaling processes If the focus is on the physiology of the nervous system, assignment could be to MDCN. If the focus is on its use as a model system to elucidate basic cellular processes and mechanisms related to membrane biology, structure, trafficking, receptors or ion channels, assignment could be to MBPP.

 

With the Oncological Sciences IRG (ONC):  Shared areas of interest are signal transduction pathways regulated by protein kinases, phosphatases and other proteins; post-translational modifications such as ubiquitinylation and sumoylation that regulate protein stability; apoptosis; membrane specializations such as caveolae and lipid rafts; and glycosylation. If the focus is on cancer biology, the assignment could be to ONC. If the focus is the elucidation of basic cellular processes and mechanisms, assignment could be to MBPP.


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[CB Small Business SEP Roster ]

The CB Small Business SEP [CB (10)] reviews grant applications from the small business community that involve application of innovative technology for analysis of cellular processes, including cell imaging and flow cytometry. Often applications will contain complementary software development. Grant applications involving innovative cell biological techniques such as cell preservation, biosensors, and tissue engineering are represented. R01 and R21 applications that are technology intensive are also assigned to CB (10).

The CB Small Business SEP has the following shared interests outside the CB IRG:

·         With the Biological Chemistry and Macromolecular Biophysics [BCMB] IRG regarding microscopic instrumentation, methodologies, or modeling for determining structure/function relationships for biological macromolecules. If the question is biochemical or biophysical, assignment to BCMB may be appropriate. If the question is cell biological, assignment to CB may be appropriate.

·         With the Bioengineering Sciences and Technologies [BST] IRG if the focus is development of new technology, assignment to BST may be appropriate.  If the focus is on a basic cell process, then assignment to CB may be appropriate.

 


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[BDPE Roster]

The Biology and Diseases of the Posterior Eye [BDPE] Study Section reviews applications for basic, applied, and clinical research on the posterior portion of the eye, i.e., that are focused on the structure, function, and disorders of the retina, retinal pigmented epithelium, choroid, and retinal vasculature. It also addresses related disorders such as degenerative and vascular diseases and retinal involvement in diabetes.

Specific areas covered by BDPE:

  • Basic research focused on the retina, retinal pigmented epithelium, choroid, and retinal vasculature; anatomy, physiology, biochemistry, biophysics, pharmacology, development, genetics, cell and molecular biology

  • Phototransduction processes in rods and cones

  • Neural interconnections in the retina and cellular electrophysiology

  • Clinical investigations and fundamental research on the etiology, prevention, diagnosis, and treatment of retinal and choroidal diseases, including degeneration, diabetes, and vascular diseases

  • Instrumentation and applications of computer technology to the retina

 

The BDPE Study Section has the following shared interests within the CB IRG:

 

Shared areas of interest include cellular processes such as trafficking, cytoskeletal interactions, cell surface or extracellular matrix molecules, cell-cell interactions, molecular studies of receptor signal transduction, and cellular signaling pathways. If the focus is the cellular process in the context of retinal physiology or disease, assignment could be to BDPE. If the focus is the fundamental cellular process with the retina being used as a model system, assignment could be to one of the other CB IRG study sections.

BDPE has the following shared interests outside the CB IRG:

·         With the Biological Chemistry and Macromolecular Biophysics [BCMB] IRG: BDPE has shared interests with BCMB regarding applications that focus on the biophysical and physical chemistry of transduction-related proteins, e.g., opsins, transducins, and phosphodiesterase; BCMB may be more appropriate if the focus is either on properties of proteins in general or on emerging biophysical or chemical approaches. BDPE may be more appropriate if the focus is on retina-specific mechanisms or outcomes.

·         With the Genes, Genomes and Genetics [GGG] IRG: BDPE has shared interests with GGG regarding applications dealing with genetic components of retinal diseases, e.g., gene structure and function, mapping, linkage, or population-based research. GGG may be appropriate if the focus is on either genetics in general or emerging genetic approaches.  BDPE may be appropriate if the focus is on retina-specific mechanisms or outcomes.

·         With the Biology of Development and Aging [BDA] IRG: BDPE has shared interests with BDA in retinal development, replication, and regeneration. If the focus is on the physiology or disease specific to the retina, assignment could be to BDPE. If the focus is on developmental or aging processes using the eye as a model system, assignment could be to the BDA IRG.

·         With the Integrative, Functional and Cognitive Neuroscience [IFCN] IRG and its Central Visual Processing [CVP] Study Section: If the question involves neurophysiological and psychophysical research applications involving the visual cortex, IFCN may be appropriate. If the focus is cell biological or eye-specific, assignment to BDPE may be appropriate.

·         With the Molecular, Cellular and Developmental Neuroscience [MDCN] IRG regarding (1) trafficking, cytoskeletal interactions, and cell surface or extracellular matrix molecules, (2) neurodegeneration, oxidative and energy metabolism, and excitotoxicity, (3) molecular, structural, and biophysical studies of signal transduction, (4) molecular transporters, ion pumps, and cellular electrophysiology, especially involving calcium, (5) neurochemical and pharmacological aspects of signal transduction, (6) regulation of cell cycle, cell specification and patterning, cell differentiation, and the initiation and regulation of rhythmicity, and (7) the development, aging, and regeneration of neural connections. If the focus is molecular neuroscience, assignment to MDCN may be appropriate. If the focus is cell biological or eye-specific, assignment to BDPE may be appropriate.

·         With the Brain Disorders and Clinical Neuroscience [BDCN] IRG and its Anterior Eye Disease [AED] Study Section: If the focus is primarily on the anterior chamber of the eye, including inflammation, immunology, and infectious diseases, BDCN may be appropriate.  BDCN may be appropriate for applications on uveitis, even if retinal cells are involved, and glaucoma.  If the focus is cell biological or posterior eye-specific, assignment to BDPE may be appropriate.

 

·         With the Cardiovascular Sciences [CVS] IRG: Vascular biology is a shared interests between CVS and BDPE. If an application concerns angiogenesis or vascular biology in general, assignment could be to CVS. If an application concerns angiogenesis or vascular biology that is specific to the retina, assignment could be to BDPE.

 


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Cell Biology and Development

[Cell Biology (CB) Integrated Review Group]

[ F05 Roster ]

F05 reviews fellowship applications in the broad areas of molecular, cellular, and developmental biology when the research focus is to understand basic principles of cell structure, function, regulation, and differentiation. The study section encompasses the scientific disciplines covered by the Cell Biology (CB) IRG and the Biology of Development and Aging (BDA) IRG. Examples of specific areas covered are listed below.

  • Gene expression and its regulation, including chromatin structure, transcription, RNA processing, translation, and RNA stability
  • Nuclear organization, including chromosomal organization and nuclear import and export
  • Biogenesis, organization, and functions of the plasma membrane and endomembrane organelles, including transmembrane transport, vesicular transport, macromolecular trafficking, and autophagy
  • Protein stability and turnover, including chaperone function and ubiquitin-based degradation and related processes
  • Signal transduction at the cellular level
  • Cell cycle and cell growth regulation
  • Cell senescence and cell death (apoptosis)
  • Cytoskeleton and cell motility
  • Cell adhesion
  • Mitosis, meiosis, and cytokinesis
  • Cell polarity
  • Extracellular matrix, including its biogenesis, organization, and interactions with the cell surface
  • Developmental cell biology, including cell fate determination, cellular basis of embryonic patterning, developmental regulation of gene expression, and cell differentiation
  • Germ and stem cell biology
Shared Interests:

With F01 (Brain Disorders and Related Neuroscience) in the area of the anterior eye: Fellowship applications on diseases of the anterior eye may be assigned to F01, while those on basic biology may be assigned as appropriate, e.g., F05 may review fellowship applications on the basic cell biology of the lens.

With F02B (Sensory, Motor, and Cognitive Neuroscience), in the area of vision: Fellowship applications dealing with visual processing and related portions of the brain, eye, and extraocular muscle system may be assigned to F02B ; Fellowship applications dealing with the biology and diseases of the posterior eye may be assigned to F05.

With F03A (Biochemical and Molecular Neuroscience): Fellowship applications focusing on development, differentiation, progenitor and stem cells, and cytoskeleton in neuronal, glial, retinal and other excitable cells may be assigned to F03A; fellowship applications focusing on basic cell structure, function, and regulation may be assigned to F05 if using neural cells as model systems.  F05 may also review fellowship applications on the basic cell biology of the retina.

With F04A (Chemical and Bioanalytical Sciences): Fellowship applications that are concerned with the mechanism of an enzyme or a system of enzymes may be assigned to F04A; fellowship applications concerned with the effects on cellular function may be assigned to F05.

With F04B (Biophysical and Biochemical Sciences) regarding cellular structure and function: Fellowship applications that are concerned with the molecular interactions among molecules that affect cellular structure may be assigned to F04B; fellowship applications that are concerned with structural and functional studies of cells and cell components when the emphasis is on molecular and cell biological context may be assigned to F05.

With F06 (Endocrinology, Nutritional Metabolism, and Reproductive Sciences): Fellowship applications that address hormone effects in the context of gonadal development through implantation of the embryo, as well as aspects of all stages of pregnancy, parturition, neonatal development and maternal/fetal physiology, may be assigned to F06. Fellowship applications that focus on signal transduction at the cellular and molecular level in context of cell division, cell cycle, cell senescence and death may be assigned to F05. Fellowship applications that focus on stem cell transformation and differentiation are of interest to both panels and should be assigned based on the thrust of the application with F05 more concerned with the basic process of cellular differentiation and F06 more concerned with the endocrinology of the stem cell line.

With F07 (Immunology): Fellowship applications on the role of the immune system in the host interaction with infectious agents, tumor cells, transplanted cells, self-components, the conceptus/fetus, allergens, and with substances encountered through environmental exposure may be assigned to F07; fellowship applications that utilize cells of the immune system as models to study basic cell function, regulation, and intracellular signaling may be assigned to F05.

With F08 (Genomics, Genetics, DNA Replication, and Gene Expression): Fellowship applications on molecular aspects of gene expression/ regulation and its relationship to chromatin/ chromosome structure and function, molecular mechanisms of meiosis, and mitosis and maintenance of the genome may be reviewed in F08; fellowship applications on nuclear organization and function, including chromosome architecture, meiosis and mitosis in relation to cell cycle, signaling of cell cycle and gene expression, and nuclear import and export may be reviewed in F05.

With F09 (Oncological Sciences): Fellowship applications that focus on understanding malignant processes concerning the regulation of cell growth, cell division, and gene expression may be reviewed in F09; fellowship applications that emphasize basic, normal cellular, molecular and developmental biology, including cell cycle, signal transduction, gene regulation, cell motility and differentiation may be reviewed by F05.

With F10 (Physiology and Pathobiology of Organ Systems): Fellowship applications that concern the structure and function of differentiated cells in a tissue, organ, or pathology context may be reviewed in F10; fellowship applications that utilize stem or differentiated cells to elucidate fundamental aspects of cell structure, function and regulation may be reviewed in F05.

With F13 (Infectious Diseases and Microbiology):  Fellowship applications that concern cell biology studies of microbes where the results will principally apply to microbes may be assigned to F13. Fellowship applications that focus on cell biology with potentially broad applications across kingdoms (i.e., crosscutting studies) or that use model organisms in nonpathogenic settings or that use viruses or their components as tools may be assigned to F05.

F14 (Technology Development): Fellowship applications that are concerned primarily with the development of new methods, instrumentation, or technology for studies of cell structure, function, regulation, and differentiation may be assigned to F14; fellowship applications that are concerned primarily with elucidating the basic principles of cell structure, function, regulation, and differentiation may be assigned to F05.


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