NIH-CSR <span id="Postingname3_PostingDisplayName">Cell Structure and Function Study Section [CSF]</span> (CBIRG)

[CSF Roster]

The Cell Structure and Function Study Section will focus on the molecular structure and function of cells, with emphasis on applications concerned with membrane structure and function, membrane traffic, organelle biogenesis, extracellular matrix (ECM), cell motility and the cytoskeleton, and their related signaling pathways.

Specific areas include, but not limited to CSF:

Organelle biogenesis (For example mitochondria, chloroplasts, peroxisomes and lysosomes/vacuoles), including organelle proliferation, segregation, and dynamics
Targeting, translocation, and processing of newly synthesized proteins at membrane compartments
Cell motility, cytoskeletal dynamics, including their role in morphogenesis
ECM interactions with the cytoskeleton, and assembly of receptors into junctions and adhesions
Mechanical properties of cells and the ECM
Signaling mechanisms related to membrane traffic, cell motility, and cell adhesion.

The CSF Study Section has the following shared interests within the CB IRG:

With the CSRS Study Section: Cell signaling is an area of shared interest. Applications focused on the translocation or recycling of signaling receptors and molecules could be reviewed in CSF. Those focused on signaling networks and cascades could be reviewed in CSRS.

With the ICI Study Section: Cell adhesion, cell motility and extracellular matrix (ECM) and ECM receptor interaction are areas of shared interest. Applications focused on the involvement of the cytoskeleton in these processes or interactions could be reviewed in CSF. Those focused on regulation of these processes or interactions by stimuli in the extracellular environment could be reviewed in ICI.

With the MBPP Study Section: Intracellular trafficking and membrane structure are an area of shared interest. Applications focused on trafficking processes that emphasize the association with the cytoskeleton could be reviewed in CSF. Applications focused on general trafficking processes could be reviewed in MBPP.

With the NDT Study Section: Motors, filaments and cargo are areas of shared interest. Applications focused on motor-based transport of vesicle cargoes or on the role of motors and filaments in cell motility could be reviewed in CSF. Those focused on the role of motors in control of cell division and chromosome dynamics in mitosis and meiosis could be reviewed in NDT.

With the MIST Study Section: Cell signaling mechanisms are an area of shared interest. Applications focused on the translocation or recycling of signaling receptors and molecules could be reviewed in CSF. Those focused on molecular and biochemical aspects of signal transduction could be reviewed in MIST.

The CSF study section has the following shared interests outside the CB IRG:

With the Bioengineering Sciences and Technologies [BST] IRG: Shared areas of interest are computational biology and cell imaging. If the focus is on the development of new imaging technologies or computational methods, the assignment could be to BST. If the focus is the use of imaging technologies or computational methods to answer questions related to cellular structure and function, assignment could be to CSF. An application that combines bioengineering and cell biology could be assigned according to the focus of the research.

With the Biological Chemistry and Macromolecular Biophysics [BMCB] IRG: Shared areas of interest are cell mechanics, the cytoskeleton, and molecular motors. If the focus is on high-resolution structural or biophysical studies of these systems, assignment could be to BCMB. If the focus is on the biological functions and mechanisms of these systems, assignment could be to CSF.

With the Cardiovascular Sciences [CVS] IRG: Shared areas of interest are cellular and molecular studies of vascular structure and function of smooth muscle. When the focus is an understanding of the biology and physiology of the cardiovascular system, assignment could be to the CVS IRG. If the focus is on a general cellular or molecular understanding of the cytoskeleton, assignment could be to CSF.

With the Digestive Sciences [DIG] and Respiratory Sciences [RES] IRGs: Shared areas of interest are intracellular trafficking, cytoskeleton function, and molecular motors. If the focus is on the physiology of the digestive system, assignment could be to DIG. If the focus is its use as model system to understand basic cell biological processes, the assignment could be to CSF.

With the Hematology [HEME] IRG: Shared interests are in the structure and function of filamentous organelles and membranes. If the focus is on the physiology of the vascular system, assignment could be to HEME. If the focus is on its use as a model system to elucidate basic processes and mechanisms related to cell structure and function, assignment could be to CSF.

With the Molecular, Cellular and Developmental Neurosciences [MDCN] IRG: Shared areas of interest are the cytoskeleton and intracellular trafficking. If the focus is on the physiology of the nervous system, assignment could be to MDCN. If the focus is on its use as a model system to elucidate basic cell processes, structure and mechanisms, assignment could be to CSF.

With the Musculoskeletal, Oral and Skin Sciences [MOSS] IRG: Shared areas of interest are muscle structure and the extracellular matrix. If the focus is on the physiology of the musculoskeletal, oral or skin, assignment could be to MOSS. If the focus is its use as model system to understand basic cell structural and functional processes, the assignment could be to CSF.

With the Oncological Sciences [ONC] IRG: Shared areas of interest are cell adhesion, motility, and junctions and extracellular matrix interaction with the cytoskeleton. If the focus is oncological processes, assignment could be to ONC. If the focus is cell biological processes, assignment could be to CSF. An application that combines normal and tumor cell biological processes could be assigned according to the focus of the research.