[NDT Roster]
The Nuclear Dynamics and Transport Study Section will consider research applications concerning nuclear aspects of growth, cell cycle control, and regulation of programmed cell death and apoptosis. Nuclear architecture, as related to the assembly of the molecular machinery responsible for RNA synthesis and processing, DNA replication, as well as trafficking into and out of the nucleus will be considered. In addition, many signaling pathways ultimately converge on the nucleus. Cytoskeletal structure and dynamics, the movement of protein and RNA cargoes utilizing molecular motors, and organelle biogenesis will also be covered. Nuclear function, structure, and motor driven movement are also integral to mitosis and meiosis, as well as programmed cell death and apoptosis.
Specific areas include, but are not limited to NDT:
- Proliferation and growth control
- Cell cycle regulation, mitosis and checkpoints
- Meiosis
- Programmed cell death and apoptosis
- Filaments, motors and cargoes
- Nuclear architecture, nuclear envelope structure and transport
- Signaling mechanisms and networks that target the nucleus
- Telomeres
The NDT Study Section has the following shared interests within the CB IRG:
With the CSRS Study Section: Cell cycle control and mitosis is an area of shared interest. Applications focused on cell cycle regulation related to nuclear architecture, chromosome function and checkpoints could be reviewed by NDT. Those focused on signaling pathways involved in cell cycle regulation could be reviewed in CSRS.
With the CSF Study Section: Motors, filaments and cargo are areas of shared interest. Applications focused on the role of motors in control of cell division and chromosome dynamics in mitosis and meiosis could be reviewed in NDT. Those focused on motor-based transport of vesicle cargoes or on the role of motors and filaments in cell motility could be reviewed in CSF.
With the MBPP Study Section: Intracellular trafficking is an area of shared interest. Applications focused on trafficking into and out of the nucleus could be reviewed by NDT. Those focused on general cytoplasmic trafficking processes could be reviewed by MBPP.
With the MIST Study Section: Cell signaling mechanisms are an area of shared interest. Applications focused on signaling mechanisms and networks that target the nucleus could be reviewed by NDT. Those focused on molecular and biochemical aspects of cytoplasmic signal transduction could be reviewed in MIST.
The NDT Study Section has the following shared interests outside the CB IRG:
With the Bioengineering Sciences and Technologies [BST] IRG: Shared areas of interest are computational biology and cell imaging. If the focus is on the development of new imaging technologies or computational methods, the assignment could be to BST. If the focus is the use of imaging technologies or computational methods to answer questions related to nuclear architecture or nucleocytoplasmic transport, assignment could be to NDT. An application that combines bioengineering and cell biology could be assigned according to the focus of the research.
With the Genes, Genomes and Genetics [GGG] IRG: Shared areas of interest are chromosome structure and dynamics, nucleocytoplasmic transport, cell cycle control, meiosis, RNA processing and nuclear protein turnover. If the focus is on nuclear envelope and nuclear pore structure and assembly, including the role of lamins, nucleoporins and cytoskeletal proteins; chromatin packaging and remodeling; and ribonucleoprotein assembly and transport through nuclear pore complexes, assignment could be to NDT. Applications focused on the molecular machinery controlling mitotic and meiotic cell divisions, including, but not limited to, the actin- and microtubule-based cytoskeleton as well as synaptonemal and kinetochore proteins could be assigned to NDT. Applications focused on signaling mechanisms targeting the nucleus, nuclear protein turnover, cell cycle regulation and programmed cell death could be assigned to NDT if the emphasis is on protein function and regulation. Applications focused primarily on nucleic acids and/or the fundamental molecular mechanisms regulating DNA replication and repair, transcription and translation could be assigned to the GGG IRG.
With the Endocrinology, Metabolism, Nutrition, & Reproductive Sciences [EMNR] IRG: Cell biology studies of gametogenesis and reproductive tract remodeling are shared interests between EMNR and NDT. If the focus is reproduction, assignment could be to the EMNR IRG. If the focus is cell biology, assignment could be to NDT.
With the Oncological Sciences [ONC] IRG: Cell growth and cycle control are areas of shared interest. If an application is focused on normal cell biological processes, assignment could be to NDT. If an application is focused on tumor cell biological processes, assignment could be to the ONC IRG. An application that combines normal and tumor cell biological processes could be assigned according to the focus of the research.
|
|