The Vascular Biology Special Emphasis Panel (ZRG1 CVS Q 90) reviews non R01 codes that would otherwise be reviewed by either the Vascular Cell and Molecular Biology (VCMB) or Atherosclerosis and Inflammation of the Cardiovascular System (AICS) Study Sections.  Accordingly, it reviews R21, R03 and R15 applications involving the cell and molecular biology of blood vessels from major arteries to the microcirculation as well as those related to inflammation of the vascular system including atherosclerosis, diabetes, transplantation, aging, autoimmunity and infection.  More detail may be found in the descriptions of the VCMB and AICS Study Sections and below:

                                    Specific areas covered by ZRG1 CVSQ 90

• Vascular homeostasis: signaling; growth control; apoptosis; cell differentiation; senescence; extracellular matrix and metalloproteinases; receptor biology; intercellular communication.
• Immune mechanisms in vascular inflammation: cytokines, chemokines, cell signaling, reactive oxygen species (ROS) influencing the vessel wall; macrophages and T cell activation and transplantation immunology related to cardiovascular disease; infective and toxicological agents promoting atherosclerosis.
• Transcriptional and posttranscriptional regulation as related to vascular biology; genomics, microarrays, bioinformatics
• Protein biochemistry of the vascular cell: protein structure; proteomics
• Endothelial barrier function: permeability and transport; permeability factors; cell junctions; ROS; platelet endothelial interactions.
• Mechanotransduction at the cellular level; hemodynamic forces; stress/strain.
• Hepatic lipoprotein metabolism and transport; lipoprotein interaction with vascular cells; LDL modification, oxidation and interaction with monocyte-macrophage forming foam cells and matrix components; vascular cell surface receptors for lipoproteins; genetics of lipoprotein metabolism.
• Injury/repair and associated angiogenesis: remodeling; angioplasty; restenosis; grafts; stents; re-endothelialization; regression of atherosclerosis; plaque stabilization; stem cells; novel interventional therapies for hyperlipidemia, inflammation and cholesterol disposal; evaluation of established devices.
• Animal models of atherosclerosis, diabetes, vasculitis, infection or lipid metabolic disorders (genetic or acquired).

ZRG1 CVS Q 90 has the following shared interests within the CVS IRG

There is a shared interest in the elements of vascular cell biology with other study sections in this IRG.  Specific shared interests of the Vascular Biology Special Emphasis are identical to those detailed under the descriptions of the VCMB and AICS Study Sections.

ZRG1 CVS Q 90 has the following shared interests outside the CVS IRG:

There are shared interests with many other IRGs and they are identical to those detailed under the descriptions of VCMB and AICS