[CE Roster]

The Cancer Etiology [CE] Study Section reviews grant applications related to the causal agents, processes, and cells involved in early events in carcinogenesis. The areas included within CE involve gene regulation, DNA damage and repair mechanisms, chemical and viral carcinogenesis. The emphasis is on linking disciplines of chemistry and pathology on the etiology of cancer.

Specific areas covered by CE include:

• Gene regulation: including transcription factors, RNA stability and processing, as they contribute to carcinogenesis.
  
  
• DNA damage and repair mechanisms related to carcinogenesis.
  
  
• Chemical- and environmental induced carcinogenesis.
  
  
• Identification of causal agents such as xenobiotics, DNA adducts, endogenous and exogenous compounds that modulate early events in carcinogenesis.
  
  
• Responses to stress such as free radicals, oxidative stress and reactive oxygen species as they contribute to the carcinogenic process.
  
  
• Metabolism of endogenous and exogenous compounds that lead to carcinogenesis
  
  
• Contribution of viruses, other than HIV/AIDS, to carcinogenesis.

CE has the following shared interests within the ONC IRG:

• With Cancer Genetics [CG]: In general, genetic studies could be assigned to CG. If the emphasis is on the mechanism of tumor etiology, then the application could be assigned to CE.
  
  

• With Molecular Oncogenesis [MONC]: In general, CE reviews studies that focus on oncogenesis induced by environmental or chemical factors, whereas MONC reviews studies that focus on understanding the fundamental processes and contributions to transformation.
  
  

• With Cancer Molecular Pathobiology [CAMP]: Studies that focus on the contribution to cell growth and apoptosis processes, oncogene and tumor suppressor functions in transformed cells could be assigned to CAMP.  If the focus is on effects of environmental or chemical carcinogens or etiology, then the application could be assigned to CE.
  
  

• With Tumor Cell Biology [TCB]: Applications that focus on signal transduction mediated by protein kinases and their signaling complexes induced by chemical or environmental carcinogens could be assigned to CE. Studies dealing with their contribution to tumor growth and progression could be assigned to TCB.
  
  

• With Radiation Therapeutics and Biology [RTB]: In general, studies related to DNA damage and repair in response to radiation could be assigned to RTB; broader studies could be assigned to CE.
   

 CE has the following shared interests outside the ONC IRG:

• With the Biological Chemistry and Macromolecular Biophysics [BCMB] IRG: In general, molecular studies not focused on the etiology of cancer would be assigned to BCMB; if the study is focused on the etiology of cancer, then it could be assigned to CE.
  
  

• With the Cell Biology [CB] IRG: In general, if the findings could also be relevant to another area of biomedical research, the application would be assigned to CB; cell studies uniquely relevant to the etiology of cancer could be assigned to CE.
  
  

• With the Genes, Genomes and Genetics [GGG] IRG: In general, gene function studies not uniquely relevant to the etiology of cancer could be assigned to GGG; studies focused on the etiology of cancer could be assigned to CE.
  
  

• With the Health of the Population [HOP] IRG: In general, if an epidemiological approach is central to the study, review could be in HOP; studies of cancer etiology could be assigned to CE.
  
  

• With the Infectious Diseases and Microbiology [IDM] IRG: In general, studies of infections as a trigger of cancer could be assigned to CE or IDM depending on the emphasis of the study; studies of the etiology of cancer could be assigned to CE. Studies dealing with the contribution of viruses such as HPV and HBV to the carcinogenic process or with translocations involving cellular oncogenes (e.g., cSrc, cAbl, cJun) could be assigned to CE.  Studies that focus on virus replication, even during viral-induced oncogenesis, could be assigned to VIRA or VIRB.
  
  

• With the AIDS and Related Research [AARR] IRG: In general, studies of the etiology of HIV/AIDS-associated cancers could be assigned to AARR.
  
  

• With the Endocrinology, Metabolism, Nutrition and Reproductive Sciences [EMNR] IRG: In general, studies of pre-neoplastic, dysplastic and hyperplastic disorders of the reproductive organs could be assigned to EMNR.  Studies of the etiology of endometrial hyperplasia; trophoblast neoplasia; germ cell tumors; pituitary adenomas; as well as thyroid, parathyroid, and adrenal tumors could be assigned to EMNR; studies of the etiology of chemically or environmentally induced tumors of reproductive organs could be assigned to CE.
  
  

• With Organ-system IRGs: In general, studies of basic biological processes unique to a specific organ system would be assigned to the appropriate organ-system IRG and studies of processes unique to the understanding of tumor etiology could be assigned to CE.

  
  

[CG Roster]

The Cancer Genetics [CG] Study Section reviews grant applications related to the causal agents and target genes involved in tumor pathogenesis.  Organ-specific carcinogenesis is included in this study section.  Studies using both mammalian and non-mammalian models are included.

Specific areas covered by CG include:

• Oncogene discovery, genomics, and proteomics (including molecular and biochemical profiling)
  
  
• Positional cloning
  
  
• Animal models for gene discovery
  
  
• Cancer genetics: including hereditary and somatic DNA alterations, allelic imbalance/LOH
  
  
• Epigenetics: including DNA methylation and imprinting
  
  
• Metabolizing enzyme polymorphisms and mutations
  
  
• Genomic instability: including microsatellite and chromosomal instability
  
  
• Susceptibility/modifier genes that modify susceptibility to cancer without allelic loss including low penetrance genes identified in human and animal models 

CG has the following shared interests within the ONC IRG:

• With Cancer Etiology [CE] in development of early biomarkers and in organ-specific carcinogenesis.  If emphasis is in the etiology of disease, the application could be assigned to CE, in general other genetic studies could be assigned to CG.
  
  
• With Tumor Progression and Metastasis [TPM] as it relates to tumor progression.  If genetic control of tumor progression is the central focus, the application could be assigned to TPM.
  
  
• With Cancer Biomarkers [CBSS] regarding discovery and evaluation of genetic and epigenetic abnormalities in tumors that may serve as clinical biomarkers.  When the focus is on identification of biomarkers for clinical applications, the proposal could be assigned to CBSS; when the focus is on understanding the disease process, the applications could be assigned to CG.
  
  
• With Radiation Therapeutics and Biology [RTB] in genomic instability: If the instability relates to radiation effects, the application could be assigned to RTB; other examples of genomic instability could be assigned to CG.
  
  
• With Drug Discovery and Molecular Pharmacology [DMP] in studies of processes and targets involved in oncogenesis. Pharmacological studies could be assigned to DMP while studies focused on cancer genetics could be assigned to CG.

CG has the following shared interests outside the ONC IRG:

• With the Genes, Genomes and Genetics [GGG] IRG:  In general, if the findings could also be relevant to another area of biomedical research, the study could be assigned to GGG; fundamental genetic and gene function studies uniquely relevant to oncology could be assigned to CG.
  
  
• With the Hematology [HEME] IRG: In general studies of the genetics of lymphoma and leukemia could be assigned to CG. 
  
  
• With the Endocrinology, Metabolism, Nutrition and Reproductive Sciences [EMNR] IRG:  In general, studies of the genetics of endometrial hyperplasia; trophoblast neoplasia; germ cell tumors; pituitary adenomas; as well as thyroid, parathyroid, and adrenal tumors could be assigned to EMNR; studies of genetics of reproductive organ tumors could be assigned to CG.
  
  
• With the Digestive Sciences [DIG] IRG: In general, genetic studies of the pre-neoplastic stages of GI, liver, or pancreas could be assigned to DIG; genetic studies of GI, liver, or pancreatic cancers could be assigned to CG.
  
  
• With the Renal and Urological Sciences [RUS] IRG:  In general, genetic studies focused on the malignant transformation in the context of urinary tract or kidney development or other diseases; or studies focused on benign processes in the kidney, urinary tract, or male genital system could be assigned to RUS; genetic studies of malignant transformation focused on the neoplastic process could be assigned to CG.  Studies of genes and their products that are involved in both neoplastic and normal developmental processes (e.g., WT1 and VHL) could be assigned to RUS or CG, depending on the focus of the study.

[MONC Roster]

The Molecular Oncogenesis [MONC] Study Section reviews applications that focus on the early molecular events that lead to oncogenic transformation such as the identification of oncogenes and tumor suppressor genes, alterations in signaling, growth, and cell cycle control pathways, and protein stability/degradation mechanisms. Applications dealing with normal developmental processes as they pertain to oncogenic transformation are also considered.

Specific areas covered by MONC include:

• Identification of oncogenes and tumor suppressor genes or alterations in their expression or function that may contribute to oncogenic transformation.
• Alterations in signal transduction pathways that may modulate or lead to oncogenic transformation.
• Proteasome-mediated degradation: Mechanisms and/or alterations of protein stability that could contribute to transformation, including post-translation modification such as ubiquitylation or sumoylation.
• Cell cycle regulation and dysregulation that may contribute to early oncogenic transformation.
• Mechanisms of immortalization as a prerequisite for oncogenic transformation.
• Biology of progenitor cells, including the identification and characterization of cancer stem cells that may be involved in oncogenic transformation.
  
  

MONC has the following shared interests within the ONC IRG:

• With Cancer Etiology [CE]: In general, studies investigating basic mechanisms and processes leading to oncogenic transformation could be assigned to MONC. Applications in which the emphasis is on tumor etiology, specifically as modulated by environmental or chemical factors, could be assigned to CE.
• With Cancer Genetics [CG]: Applications that focus on understanding signaling pathways that modulate genomic instability could be assigned to MONC.  Applications that focus on genetic analysis could be assigned to CG.
• With Cancer Molecular Pathobiology [CAMP]:  In general, studies on the basic signaling mechanisms contributing to oncogenic transformation could be assigned to MONC. Studies that focus on transcriptional regulation in the oncogenic transformation process could be assigned to CAMP. Studies that focus on the identification and/or characterization of cancer stem cells could be assigned to MONC. Studies that focus on the role of stem cells could be assigned to CAMP.
• With Tumor Cell Biology [TCB]: Applications with an emphasis on basic cell cycle control or signal transduction pathways related to oncogenic transformation could be assigned to MONC.  Applications in which the emphasis is on cell cycle control and growth factors signal transduction pathways in tumors and tumor progression could be assigned to TCB.
• With Chemo/Dietary Prevention [CDP]: Applications with an emphasis on cancer prevention could be assigned to CDP. Applications with an emphasis on the basic mechanism of oncogenesis could be assigned to MONC.
  
  

MONC has the following shared interests outside the ONC IRG:

• With the Biological Chemistry and Macromolecular Biophysics [BCMB] IRG: In general, applications that focus on understanding the function of biological molecules and their interactions in normal or non-tumorigenic cells could be assigned to BCMB. Applications that focus on the function of biological molecules during oncogenic transformation could be assigned to MONC.
• With the Cell Biology [CB] IRG: In general, applications that focus on normal cellular biological processes could be assigned to CB and applications that focus on processes associated with oncogenic transformation could be assigned to MONC. Studies that evaluate both normal cell biological processes and processes critical for transformation would be assigned to an IRG according to the main focus of the proposed research.
• With Biology of Development and Aging [BDA] IRG: In general, applications that focus on biological processes associated with normal development and aging could be assigned to BDA. Applications that focus on development and aging as they relate to early events in oncogenesis could be assigned to MONC.
• With the Endocrinology, Metabolism, Nutrition and Reproductive Sciences [EMNR] IRG: In general, studies that focus on pre-neoplastic, dysplastic, hyperplastic disorders of the reproductive organs or that focus on cancers originating in endocrine glands could be assigned to EMNR. Studies with an emphasis on the basic biology or on the signaling pathways that modulate the early oncogenic events in these organs could be assigned to MONC.
• With the Organ-System IRGs: In general, studies of biological processes in normal or non-tumorigenic cells could be assigned to the appropriate organ-system IRG and studies directed at understanding the process of organ-specific oncogenic transformation could be assigned to MONC.

[CAMP Roster]

Specific areas covered by CAMP include:

• Oncogenes and tumor suppressor genes and their pathways in oncogenesis.
  
  
• Gene regulation including chromatin structure and remodeling, RNA stability, transcription and translation relevant to oncogenesis.
  
  
• Signaling transduction pathways related to the regulation of cell growth in cancer.
  
  

• Role of characterized stem cells in oncogenesis.
  
  

• Mechanisms of overcoming senescence in the context of oncogenesis.
  
  

• Cell death pathways (both apoptotic and non-apoptotic) in cancer.
  
  

• Mechanisms mediated through telomeres and telomerase in oncogenesis.

  
  

CAMP has the following shared interests within the ONC IRG:

• With Cancer Etiology [CE]: Studies that focus on the contribution of cell growth and apoptosis processes, oncogene and tumor suppressor functions in transformed cells could be assigned to CAMP.  If the focus is on effects of environmental or chemical carcinogens, then the application could be assigned to CE.
  
  
• With Cancer Genetics [CG]: Applications that focus on transcriptional regulation of oncogenes or tumor suppressors could be assigned to CAMP.  If the focus is on gene discovery or other genetic studies, then the application could be assigned to CG.
  
  
• With Molecular Oncogenesis [MONC]:  In general, studies on the basic signaling mechanisms contributing to oncogenic transformation could be assigned to MONC. Applications that focus on transcriptional regulation in the oncogenic transformation process could be assigned to CAMP. Studies that focus on the identification or characterization of cancer stem cells could be assigned to MONC. Studies that focus on the role of cancer stem cells could be assigned to CAMP.
  
  
• With Tumor Cell Biology [TCB]: Applications that focus on signal transduction primarily related to cell growth and/or apoptosis could be assigned to CAMP.  Other growth factor/signaling applications in tumors could be assigned to TCB.
  
  
• With Basic Mechanisms of Cancer Therapeutics [BMCT]: Basic studies of the biology/pathology of the malignant cell could be assigned to CAMP.  If the study is therapeutically oriented, then it could be assigned to BMCT.
  
  

CAMP has the following shared interests outside the ONC IRG:

• With the Cell Biology [CB] IRG: In general, studies of normal cell biology processes could be assigned to CB and processes of cell biology that are critical in tumor cells could be assigned to CAMP. Studies that combine both normal cell biological processes and processes critical for transformation would be assigned to an IRG according to the main focus of the research.
  
  
• With the Genes, Genomes and Genetics [GGG] IRG: In general, studies of normal gene regulatory processes could be assigned to GGG, whereas gene regulation processes in transformed cells could be assigned to CAMP.  Studies that combine both normal regulatory processes and processes critical for transformation and/or tumor progression would be assigned to an IRG according to the main focus of the research.
  
  
• With the Biology of Development and Aging [BDA] IRG: In general, studies that focus on oncogenes and tumor suppressors in the context of development or aging could be assigned to BDA.  Studies that focus on oncogenes and tumor suppressors in the context of cancer biology could be assigned to CAMP.
  
  
• With the Endocrinology, Metabolism, Nutrition and Reproductive Sciences [EMNR] IRG: In general, studies that focus on pre-neoplastic, dysplastic, hyperplastic disorders of the reproductive organs or that focus on cancers originating in endocrine glands could be assigned to EMNR. Studies with an emphasis on tumor suppressors or survival (apoptotic or non-apoptotic) pathways could be assigned to CAMP.
  
  
• With the Organ-system IRGs: In general, studies of normal cell biology processes unique to a specific organ system could be assigned to the appropriate organ-system IRG and studies of such mechanisms in neoplasias could be assigned to CAMP.

[TCB Roster]

The Tumor Cell Biology [TCB] Study Section reviews applications focusing on signal transduction and growth factor regulation in neoplasias and tumor progression.

Specific areas covered by TCB include:

• Signal transduction mediated by protein kinases, phosphatases, and other proteins, including signaling mediated by hypoxia, inflammation, and nutrient sensing mechanisms.
  
  
• Signaling by cell surface receptors, growth factors, cytokines, and associated proteins. This includes analyses of the composition, formation and functioning of signaling complexes in tumor progression and in tumor cells.
  
  
• Analysis of interactions among signaling pathways in tumor cells and tumor progression.
  
  
• Pathways regulated by oncogenes and tumor suppressor genes; how these genes alter signaling in neoplasms and the consequences of these alterations on tumor cell phenotype and physiology.
  
  
• Hormonal modulation of carcinogenesis, including endocrine signaling as it relates to tumorigenesis, steroid metabolism, and hormone receptors.
  
  
• Differentiation and transdifferentiation in neoplasias.
  
  

• Signal transduction mediated by the cytoskeleton as it relates to tumorigenesis and tumor progression.

TCB has the following shared interests within the ONC IRG:

• With Cancer Etiology [CE]: Applications that focus on signal transduction mediated by protein kinases and their signaling complexes in chemically or environmentally induced carcinogenesis could be assigned to CE. Studies dealing with their contribution to tumor growth and progression could be assigned to TCB.
  
  

• With Molecular Oncogenesis [MONC]: Applications that focus on the basic signal transduction mechanisms primarily related to cell cycle/checkpoints, growth factors, or oncogenes in oncogenic transformation could be assigned to MONC.  Other growth factor/signaling applications in neoplasias could be assigned to TCB.
  
  

• With Cancer Molecular Pathobiology [CAMP]: Applications that focus on the basic mechanisms primarily related to cell survival regulation, oncogenes and tumor suppressors in malignant cells could be assigned to CAMP.  Such studies on tumors and tumor progression could be assigned to TCB.
  
  

• With Chemo/Dietary Prevention [CDP]: Applications that focus on nutrient induced signaling pathways that modulate tumor growth could be assigned to TCB. If the emphasis is on cancer prevention the application could be assigned to CDP.
  
  

• With Cancer Biomarkers [CBSS]: Applications that focus on the development of novel biomarkers and diagnostic signatures could be assigned to CBSS. If related to tumor cell growth, then the application could be assigned to TCB.
  
  

• With Tumor Microenvironment [TME]:  Applications that focus on the effects of extracellular actions of growth factors and other cytokines could be assigned to TME, whereas those focusing on intracellular signaling could be assigned to TCB.
  
  

• With Tumor Progression and Metastasis [TPM]: Applications that focus on the effects of hypoxia on tumor cell invasion could be assigned to TPM, whereas those focusing on tumor growth and early stages of progression could be assigned to TCB.
  
  

• With Developmental Therapeutics [DT]: Studies relating to signal transduction, cell cycle, and differentiation in the context of drug development could be assigned to DT. If the study focuses on tumor cell growth and phenotype, then it could be assigned to TCB.

   

TCB has the following shared interests outside the ONC IRG:

• With the Cell Biology [CB] IRG: In general, studies of signaling in normal cells could be assigned to CB; studies of signaling processes in neoplasms and their progression could be assigned to TCB.  Proposals that combine studies of signaling in both normal cells and in neoplastic cells would be assigned to an IRG according to the main focus of the proposal.
  
  

• With the Genes, Genomes and Genetics [GGG] IRG: In general, studies of how genes alter signaling in normal cells and the consequences of those alterations could be assigned to GGG; studies of how genes alter signaling in neoplasms and the consequences of those alterations could be assigned to TCB.  Proposals that combine studies of gene alterations of signaling in both normal and neoplastic cells would be assigned to an IRG according to the main focus of the proposal.
  
  

• With the Endocrinology, Metabolism, Nutrition and Reproductive Sciences [EMNR] IRG:  In general, studies of endometrial hyperplasia; trophoblast neoplasia; germ cell tumors; pituitary adenomas; as well as thyroid, parathyroid, and adrenal tumors could be assigned to EMNR; studies of tumors in reproductive organs could be assigned to TCB.  Studies of obesity or insulin resistance as a risk factor for cancer and if the focus is on mechanisms of metabolic fuel homeostasis or insulin action on cell growth could be assigned to EMNR; studies focusing on the mechanism of tumor progression could be assigned to TCB.
  
  

• With the Digestive Sciences [DIG] IRG:  Studies of familial adenomatous polyposis (FAP) as well as the pathology and treatment of polyps in the GI system could be assigned to the DIG IRG.  In general, cell biological studies of GI, liver, or pancreatic cancers could be assigned to TCB.  Studies of Barrett's Esophagus physiology could be assigned to DIG or TCB depending on the focus of the study. 
  
  

• With the Organ-system IRGs: In general, studies of signaling processes unique to cells in a specific organ system would be assigned to the organ-system IRG; studies of signaling directed toward understanding oncogenesis could be assigned to TCB.
  
  

• With the Brain Disorders and Clinical Neuroscience [BDCN] IRG: In general, studies of tumor physiology and pathology of the brain could be assigned to BDCN; studies for which a brain tumor is being used as a model system could be assigned to TCB.

[TME Roster]

The Tumor Microenvironment [TME] Study Section reviews grant applications that deal with basic mechanisms of cancer cell interactions with host systems including: immune, inflammatory, stromal, vascular, and extracellular matrix.  Emphasis is on evaluation of the tumor as an organ-like structure with complex, dynamic cross-talk.  Included are studies of cell adhesion molecules, cell-cell interactions and alterations of extracellular matrix.  Studies of tumor angiogenesis, involvement of tumor lymphatic components, and organ-specific metastasis are assigned to this study section. 

Specific areas covered by TME include:

• Molecular and cellular aspects of tumor cell biology (including gap junctions, adherens, and tight junctions) and cross-talk with host cells (including connective tissue cells, immune cells, inflammatory cells, and vascular compartments). 
  
  
• Bi-directional interactions (feedback) during neoplastic progression, angiogenesis and metastasis. 
  
  
• Cellular and molecular aspects of epithelial-mesenchymal transition and transactivation as it relates to tumor progression.
  
  
• Development and exploration of physiologically responsive organotypic models, and models of other tissue-like processes such as angiogenesis, that allow investigation of tumor cells in the context of a tissue-like environment. 
  
  
• Evaluation of cell-matrix adhesion and its dynamic changes during tumor progression.  Dynamics of cell-cell communication for cell survival, growth, and invasion.  Included are studies of inter-cellular signaling and production of paracrine factors (including TGF-beta) that regulate matrix formation and remodeling.
  
  
• Development and investigation of models for studying organ-specific metastases, including crucial interactions between metastatic cells and bone/bone marrow microenvironment or with other site-specific organs. 

TME has the following shared interests within the ONC IRG:

• With Tumor Cell Biology [TCB]: Growth factors in the context of intracellular signaling could be assigned to TCB; growth factor biology, as it affects tumor progression and metastasis, could be assigned to TME.
  
  
• With Tumor Cell Biology [TCB]:  Activity of modulators of tumor cell adhesion, shape, motility, and invasion as it pertains to intracellular signaling pathways could be assigned to TCB, whereas applications dealing with signals from cells and extracellular matrix could be assigned to TME.
  
  
• With Tumor Progression and Metastasis [TPM]: Studies that focus on the role of angiogenesis for progression of tumors could be assigned to TPM; studies of angiogenesis, as it relates to the tumor microenvironment, could be assigned to TME. 
  
  
• With Cancer Biomarkers [CBSS] regarding "host factors" such as immune signatures and vascular compartments.  If the study concerns development of diagnostic biomarkers it could be assigned to CBSS, otherwise it could be assigned to TME.
  
  
• With Radiation Therapeutics and Biology [RTB] regarding tumor microenvironment:  Studies of tumor microenvironment that relate to radiation biology (e.g., hypoxia) could be assigned to RTB; other studies of tumor microenvironment could be assigned to TME.

TME has the following shared interests outside the ONC IRG:

• With the Hematology [HEME] and Cardiovascular Sciences [CVS] IRGs: In general, studies of angiogenesis that are focused on developmentally related processes or reactivation of embryonic processes could be assigned to HEME or CVS; studies focused on tumor angiogenesis could be assigned to TME.
  
  
• With the Endocrinology, Metabolism, Nutrition and Reproductive Sciences [EMNR] IRG:  In general, studies of the interaction of hormones with endocrine glands or reproductive organs and their microenvironment could be assigned to EMNR; studies of hormonal regulation of endocrine tumors could be assigned to EMNR and hormonal regulation of other tumors to TME. 
  
  
• With the Musculoskeletal, Oral, and Skin Sciences [MOSS] IRG: In general, studies of the interaction of musculosketal, oral, skin, and bone cells with the tumor microenvironments could be assigned to MOSS; studies focused on tumor cell- microenvironment interactions could be assigned to TME.
  
  
• With the Digestive Sciences [DIG] IRG: In general, studies of the interactions of pre-neoplastic cells of the GI, liver, or pancreas with their microenvironments could be assigned to DIG; studies of the interactions of tumor cells from GI, liver or pancreatic with their microenvironment could be assigned to TME.

[TPM Roster]

The Tumor Progression and Metastasis [TPM] Study Section reviews grant applications that deal with basic mechanisms of cancer progression and metastasis.  Special emphasis is placed on angiogenesis, hypoxia, invasion, migration/motility and tumor cell extravasation, intravasation, survival, adhesion and growth.  Studies focusing on proteases, wound healing and extracellular matrix remodeling, cell adhesion molecules/integrins will also be assigned to this study section.  These include in vitro and animal studies of malignancies. 

Specific areas covered by TPM:

• Mechanisms and contributions of angiogenesis and lymphoid components in both pre-malignant and malignant stages of tumor progression (including the roles of hypoxia, angiogenic factors and their receptors).
  
  
• Studies of tumor cell invasion, migration, and motility (including tumor cell intravasation and extravasation).
  
  
• Studies on the basic biology of metastasis (including adhesion, growth, and modification of the extracellular matrix environment).
  
  
• Studies of the role of proteases and remodeling of extracellular matrix as it relates to tumor progression and metastasis.
  
  
• Studies of the mechanisms and roles of wound healing as they relate to tumor progre