[CMBK Roster]
The Cellular and Molecular Biology of the Kidney [CMBK] Study Section reviews grant applications involving basic and applied aspects of normal and abnormal renal physiology, cell biology, transport biology, including osmoregulation and osmosensing, hormone action and signal transduction, vascular biology, genetic disorders, cell-matrix interactions, biophysics, and bioenergetics.
Specific areas covered by CMBK:
-
Molecular biology and physiology of transport systems (e.g., water channels, cotransporters, organic solutes, and ion channels) broadly relevant to renal function and disease; structure-function relationships; regulation of function; synthesis and degradation of cellular components; and disorders of transport function, both acquired and inherited.
Protein trafficking and cell polarity; protein turnover and targeting; cell-matrix interactions; protein synthesis; and regulation of gene expression and other processes relevant to the function of renal tubular epithelial, vascular, and interstitial cells.
Disorders of tubular epithelial and endothelial cells as they relate to kidney diseases.
Identification and characterization of genes that cause kidney diseases in humans and animal models. Pathophysiology and cellular and molecular consequences of genetic disorders (including polycystic kidney disease and disorders of tubular function).
Integrated aspects of disordered fluid, electrolyte, and acid-base homeostasis resulting from abnormalities in the transport systems; blood pressure and extracellular fluid volume homeostasis; hormonal and autocoid regulation of renal and urinary tract function; neural regulation; and abnormal transport systems causing hypertension.
Pharmacology relating to kidney function.
CMBK has the following shared interests within the RUS IRG:
-
With Pathobiology of Kidney Disease [PBKD]: (1) Hypertension: Applications related to the effects of hypertension or the hemodynamics of hypertension could be assigned to PBKD. Applications that focus on 1) the genetics of renal hypertension or vascular regulation or 2) cell physiology, transport, or channel abnormalities contributing to the development of hypertension, could be assigned to CMBK. (2) Genetic diseases. Applications related to organ physiology and consequences of genetic diseases could be assigned to PBKD. Also, studies that relate to alterations in the structure or function of the glomerulus could be assigned to PBKD. Applications related to genetic diseases affecting renal tubular epithelial cells, as well as those studying effects on the structure or function of affected proteins, could be assigned to CMBK. (3) Proteinuria and nephrotic syndrome. Studies of the pathogenesis of proteinuria and clinical studies of nephrotic syndrome could be assigned to PBKD, whereas studies of integrated handling of renal salt and water excretion in the pathogenesis of edema could be assigned to CMBK. (4) Progression of renal disease. Applications dealing with factors that influence the progression of disease or organ pathophysiology, whether clinical or in experimental models, are most appropriate for PBKD. Those that address cell physiology, including cell signaling, trafficking, polarity, transport or channel properties could be assigned to CMBK. (5) Diabetic nephropathy. Applications dealing with factors that influence the susceptibility to diabetic nephropathy, its initiation, progression, and pathophysiology (whether clinical or involving in vivo or in vitro experimental models) are most appropriate for PBKD. Those that address cell physiology (including cell signaling, trafficking, polarity, transport or channel properties) could be assigned to CMBK. (6) Pathogenesis and manifestations of cystic kidney disease. Clinical and basic studies of the effects of cystic diseases on renal function could be assigned to PBKD. Molecular and clinical genetic studies in humans and animal models are more appropriate for CMBK, as are studies of the transport properties of cystic epithelia.
-
With Urologic and Kidney Development and Genitourinary Diseases [UKGD]: Applications related to pathogenesis of stone formation, the effects of stones, and treatment of stone disease could be assigned to UKGD. Applications related to abnormal transport systems and membrane biology related to stone formation could be assigned to CMBK.
CMBK has the following shared interests outside the RUS IRG:
-
With the Biological Chemistry and Macromolecular Biophysics [BCMB] IRG: Studies examining the structure and function of membranes or proteins involved in ion transport mechanisms, including signal transduction and bioenergetics, that address questions relative to the physiology or pathology of the kidney, are appropriate for CMBK. Studies designed to address general principles of ion transport, signal transduction or bioenergetics, and that use kidney elements primarily as a convenient source of material, may be considered under the auspices of the BCMB IRG. In general, studies of kidney structure and function that use primarily biophysical techniques (e.g., X-ray crystallography, electron microscopy/image reconstruction, electron spin resonance, and single molecular techniques) would be assigned to the BCMB IRG.
-
With the Cell Biology [CB] IRG: Applications related to general questions of epithelial cell biology with no apparent application to the kidney and its function could be assigned to the CB IRG. Applications related to questions of cell biology related to renal function and disease could be assigned to CMBK.
-
With the Genes, Genomes & Genetics [GGG] IRG: Studies directed at the renal or urological system could be assigned to CMBK if the focus is primarily on the elucidation of specific known disease mechanisms, molecules, or pathways in the genitourinary system. This would include the study of known genes or the use of established technologies to study non-Mendelian, complex diseases or Mendelian diseases. Applications that focus on general questions of gene discovery, genetic dissection of complex diseases, or development of emerging genetic technology could be assigned to GGG.
-
With the Biology of Development and Aging [BDA] IRG: Studies of the kidney and aging are shared with the BDA IRG. Basic and clinical studies on aging that address questions specifically applicable to the kidney may be assigned to CMBK. Studies that use the kidney as a model to address questions having broad applicability for the biology of aging, or studies involving the kidney and interactions with age-related changes in other physiological systems could be assigned to the BDA IRG.
-
With the Cardiovascular Sciences [CVS] IRG: Applications related to the molecular basis of disorders causing abnormal function of ion channels that result in hypertension may be assigned to either the CVS IRG or CMBK according to the central focus of the application. Applications related to non-renal aspects of hypertension may be assigned to the CVS IRG. Applications that focus on the genetics, vascular regulation, cell physiology, transport, or channel abnormalities contributing to the development of hypertension associated with renal insufficiency or end-stage renal disease may be assigned to CMBK.
-
With the Digestive Sciences [DIG] IRG: Shared interests exist in areas such as renal transport mechanisms and drug therapy. Studies could be assigned to the DIG IRG when the kinetics, dynamics and mechanisms address disposition and effects of drugs where multiple organ systems are involved, or where the hepatic and/or gastrointestinal activities dominate. Pharmacology relating to kidney function and toxic injury to the kidney, including xenobiotic-mediated alterations, could be assigned to CMBK. This would include applications where multiple organ systems are involved if the transport systems are known to be essential for kidney function such as aquaporin or polycystin.
-
With the Integrative, Functional and Cognitive Neuroscience [IFCN] IRG: There is a shared interest in the neural control of renal function. Applications focusing on the central nervous system dealing with thirst could be assigned to the IFCN IRG. Applications on the central nervous system regulation of renal function could be assigned to CMBK.
|
|