[XNDA Membership Roster] [XNDA Meeting Rosters]
The Xenobiotic and Nutrient Disposition and Action [XNDA] Study Section reviews applications related to the disposition of xenobiotics and supraphysiologic (SP) levels of nutrients and non-nutrient chemicals, including pro-drugs and drugs, biopharmaceutical agents, alcohol, toxins, phytochemicals/ botanicals and environmental toxicants, and the study of their mechanisms of action (both pharmacological and toxicological) in normal and pathological conditions of the digestive system, kidney and genitourinary system, as well as in multi-organ systems.
Specific areas covered by XNDA:
- Gastrointestinal, hepatic, renal, urological or multi-organ disposition and effects of xenobiotics, SP nutrients and non-nutrient chemicals including processes of absorption. biotransformation, distribution, toxicity and excretion.
- Structure-function relationships for enzymes/transporters/receptors involved in SP nutrient, non-nutrient chemicals and/or xenobiotic disposition and toxic effects.
- Role of genetics and genomics in disposition and effects of SP nutrients, non-nutrient chemicals and xenobiotics (e.g., pharmacogenetics, pharmacogenomics, toxicogenetics, toxicogenomics).
- Theoretical, mechanistic, and/or integrated studies of kinetics and/or dynamics of SP nutrients, non-nutrient chemicals and xenobiotics (e.g., pharmacokinetics, pharmacodynamics, toxicokinetics and toxicodynamics).
- Interactions among xenobiotics (e.g., drug-drug interactions, nutrient-drug interactions, alcohol-drug interactions), involving disposition and response processes. In vitro and in vivo models that study the molecular basis of gene-environment interactions related to the digestive system, renal, urological or multi-organ systems, including studies focused on putative environmental susceptibility genes.
- Mechanisms of action of xenobiotics, non-nutrient chemicals and SP nutrients, including toxicological and/or pharmacological effects on the digestive system, renal, urological or multi-organ systems.
Study sections with most closely related areas of similar science listed in rank order are:
Hepatobiliary Pathophysiology [HBPP]
Cancer Etiology Study Section [CE]
Chemo/Dietary Prevention Study Section [CDP]
Drug Discovery and Molecular Pharmacology [DMP]
Integrative Nutrition and Metabolic Processes [INMP]
Macromolecular Structure and Function A Study Section [MSFA]
Macromolecular Structure and Function B Study Section [MSFB]
Macromolecular Structure and Function C Study Section [MSFC]
Macromolecular Structure and Function D Study Section [MSFD]
Macromolecular Structure and Function E Study Section [MSFE]
Revised 12/6/2010
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